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Automated SPE Sample Preparation for GLP‑1 Analogs from Plasma
This basic method provides the core methodology for translating a workflow into OneLab-executable script(s) as an attempt to fully or semi-automate a specific procedure. It demonstrates the benefits of automation and highlights OneLab capabilities and best practices to promote solution adoption, helping transition from manual to a more automated approach. It can be used alone or serves as a building block for a more complex workflow and is easily adaptable to users' requirements.

Published by
Waters Corporation
Version 1, 22 May 2026 at 6:02 PM
This method describes an automated SPE workflow for preparing five GLP‑1 analogs from rat plasma using Andrew+ and Extraction+. It provides reproducible recovery, low matrix effects, and reduced hands‑on time, supporting efficient and traceable LC‑MS/MS bioanalysis.
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Please note that this is a “Tutorial Method”
This basic method provides the core methodology for translating a workflow into OneLab-executable script(s) as an attempt to fully or semi-automate a specific procedure. It demonstrates the benefits of automation and highlights OneLab capabilities and best practices to promote solution adoption, helping transition from manual to a more automated approach. It can be used alone or serves as a building block for a more complex workflow and is easily adaptable to users' requirements.
Overview
Protocols
1

GLP‑1 Analogs Extraction from Plasma
Sample pre-treatment, extraction and dilution
Contact info

Published by
Waters Corporation
From the everyday consumer to scientists in the laboratory, we all rely on accurate information to make critical decisions. Waters Corporation is the world's leading specialty measurement company focused on improving human health and well-being through the application of high-value analytical technologies and industry leading scientific expertise.
This is an open access protocol distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 